GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9876781 | 1 | rs6776700 | chr3:48496758 | TREX1 | chr3:48501186-48509043:+ | -0.26 | -6 | 3.88E-9 | Longevity |
| THCA | cis | rs583583 | 1 | rs677977 | chr1:147083744 | ACP6 | chr1:147119168-147142634:- | -0.75 | -15.8 | 1.58E-45 | Schizophrenia (negative symptoms) |
| THCA | cis | rs2274273 | 1 | rs67805055 | chr14:55587552 | KIAA0831 | chr14:55833110-55878576:- | -0.12 | -3.46 | 0.000582 | Protein biomarker |
| THCA | cis | rs9815354 | 1 | rs6781326 | chr3:41777028 | ULK4 | chr3:41288091-42003660:- | 1.05 | 19.46 | 1.48E-62 | Diastolic blood pressure |
| THCA | cis | rs1552244 | 1 | rs6781811 | chr3:10121922 | C3orf10 | chr3:10157333-10168873:+ | 0.19 | 4.12 | 4.39E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6781811 | chr3:10121922 | VHL | chr3:10183319-10193744:+ | 0.17 | 3.89 | 0.000115 | Alzheimer's disease |
| THCA | cis | rs10935120 | 1 | rs6782563 | chr3:134295959 | ANAPC13 | chr3:134196547-134204865:- | -0.36 | -11.4 | 8.25E-27 | Height |
| THCA | cis | rs10935120 | 1 | rs6782563 | chr3:134295959 | CEP63 | chr3:134204575-134293852:+ | -0.3 | -6.62 | 9.81E-11 | Height |
| THCA | cis | rs1552244 | 1 | rs6782602 | chr3:10116541 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.19 | 3.28E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6782602 | chr3:10116541 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.47 | 9.88E-6 | Alzheimer's disease |
| THCA | cis | rs6805251 | 1 | rs6782799 | chr3:119610793 | GSK3B | chr3:119540804-119813264:- | 0.14 | 4.81 | 2.01E-6 | HDL cholesterol |
| THCA | cis | rs515910 | 1 | rs678292 | chr10:105957561 | C10orf79 | chr10:105889647-105992120:- | 0.24 | 7.9 | 1.89E-14 | Attention deficit hyperactivity disorder |
| THCA | cis | rs9815354 | 1 | rs6783001 | chr3:41862232 | ULK4 | chr3:41288091-42003660:- | 1.1 | 21.29 | 2.98E-71 | Diastolic blood pressure |
| THCA | cis | rs7647973 | 1 | rs6783003 | chr3:49524778 | GMPPB | chr3:49758932-49761384:- | 0.16 | 3.71 | 0.000228 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6783003 | chr3:49524778 | P4HTM | chr3:49027341-49044579:+ | -0.18 | -4.5 | 8.58E-6 | Menarche (age at onset) |